成人、青少年和儿童进行双盲、安慰剂对照食物挑战后的食物过敏相关生活质量。
Food allergy-related quality of life after double-blind, placebo-controlled food challenges in adults, adolescents, and children.
机构信息
Department of Pediatrics, Division of Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
出版信息
J Allergy Clin Immunol. 2012 Nov;130(5):1136-1143.e2. doi: 10.1016/j.jaci.2012.05.037. Epub 2012 Jul 24.
BACKGROUND
Currently, the longitudinal validity (validity over time) and responsiveness (ability to measure change over time) of the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF), the Food Allergy Quality of Life Questionnaire-Teenager Form (FAQLQ-TF), and the Food Allergy Quality of Life Questionnaire-Child Form (FAQLQ-CF) are unknown. Additionally, the self-reported impact of a double-blind, placebo-controlled food challenge (DBPCFC) on health-related quality of life (HRQL) in adults (≥18 years of age), adolescents (13-17 years of age), and children (8-12 years of age) is unknown.
OBJECTIVE
The aims of this study were to assess the longitudinal validity and responsiveness of the FAQLQ-AF, FAQLQ-TF, and FAQLQ-CF and to assess the impact of a DBPCFC on HRQL.
METHODS
Two hundred twenty-one participants suspected of food allergy were included from Dutch allergy centers. Participants undergoing a DBPCFC (experimental group) completed the FAQLQ and Food Allergy Independent Measure (FAIM) 1 month before (baseline) and 6 months after (follow-up) a DBPCFC. Participants not undergoing a DBPCFC (control group) completed the questionnaire package twice with a 7-month interval.
RESULTS
HRQL scores improved after a DBPCFC, with greater improvements in HRQL scores after a negative outcome (food allergy ruled out) than a positive outcome (food allergy confirmed), demonstrating responsiveness of the FAQLQs. Significant correlations were shown between the change (follow-up minus baseline) in FAQLQ and FAIM scores supporting longitudinal validity of these questionnaires: FAQLQ-AF (Pearson correlation coefficient = 0.71, P < .001), FAQLQ-TF (Pearson correlation coefficient = 0.35, P = .018), and FAQLQ-CF (Pearson correlation coefficient = 0.51, P < .001).
CONCLUSIONS
Our findings demonstrate the longitudinal validity and responsiveness of the FAQLQs. Greater improvements in HRQL scores were shown after a negative outcome than after a positive outcome.
背景
目前，食物过敏生活质量问卷成人版（FAQLQ-AF）、青少年版（FAQLQ-TF）和儿童版（FAQLQ-CF）的纵向有效性（随时间的有效性）和反应性（随时间测量变化的能力）以及双盲、安慰剂对照食物挑战（DBPCFC）对成年人（≥18 岁）、青少年（13-17 岁）和儿童（8-12 岁）健康相关生活质量（HRQL）的自我报告影响尚不清楚。
目的
本研究旨在评估 FAQLQ-AF、FAQLQ-TF 和 FAQLQ-CF 的纵向有效性和反应性，并评估 DBPCFC 对 HRQL 的影响。
方法
从荷兰过敏中心纳入 221 名疑似食物过敏的参与者。接受 DBPCFC（实验组）的参与者在 DBPCFC 前 1 个月（基线）和 6 个月后（随访）完成 FAQLQ 和食物过敏独立测量（FAIM）。未接受 DBPCFC（对照组）的参与者在 7 个月的间隔内两次完成问卷包。
结果
DBPCFC 后 HRQL 评分有所改善，阴性结果（排除食物过敏）后的 HRQL 评分改善大于阳性结果（确认食物过敏），表明 FAQLQs 的反应性。FAQLQ 和 FAIM 评分变化（随访减去基线）之间显示出显著相关性，支持这些问卷的纵向有效性：FAQLQ-AF（Pearson 相关系数=0.71，P<.001）、FAQLQ-TF（Pearson 相关系数=0.35，P=0.018）和 FAQLQ-CF（Pearson 相关系数=0.51，P<.001）。
结论
我们的研究结果表明，FAQLQs 具有纵向有效性和反应性。阴性结果后 HRQL 评分的改善大于阳性结果后。
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