Pak-Dek M S, Abdul-Hamid A, Osman A, Soh C S
Dept. of Food Science, Faculty of Food Science and Technology, Univ. Putra Malaysia, UPM 43400, Serdang, Selangor, Malaysia.
J Food Sci. 2008 Oct;73(8):C595-8. doi: 10.1111/j.1750-3841.2008.00929.x.
Efficacy of Morinda citrifolia L. leaf (MLE) and fruit extracts (MFE) in inhibiting lipoprotein lipase (LPL) was determined in vitro. The result of the study showed that the highest inhibition on the LPL activity was exhibited by MLE (66%+/- 2.1%), which is significantly higher than that demonstrated by MFE (54.5%+/- 2.5%), green tea extract (GTE) (54.5%+/- 2.6%), and catechin (43.6%+/- 6.1%). Percent of LPL inhibition increase with concentration of the extracts. Quantitative analysis of the extracts revealed the presence of high levels of (+)-catechin at 63.5 +/- 17 and 53.7 +/- 5.7 mg/g in MLE and MFE, respectively, although not as high as that found in GTE (530.6 +/- 42 mg/g). Appreciable amount of epicatechin was found in all extracts tested, while rutin was only found in MLE and MFE. The study suggested that both leaf and fruit of M. citrifolia may be used as antiobesity agents in body weight management.
体外测定了海巴戟叶提取物（MLE）和果实提取物（MFE）对脂蛋白脂肪酶（LPL）的抑制效果。研究结果表明，MLE对LPL活性的抑制作用最强（66%±2.1%），显著高于MFE（54.5%±2.5%）、绿茶提取物（GTE）（54.5%±2.6%）和儿茶素（43.6%±6.1%）。LPL抑制率随提取物浓度的增加而升高。提取物的定量分析显示，MLE和MFE中（+）-儿茶素含量较高，分别为63.5±17和53.7±5.7 mg/g，不过不如GTE中的含量高（530.6±42 mg/g）。在所有测试提取物中均发现了可观含量的表儿茶素，而芦丁仅在MLE和MFE中被发现。该研究表明，海巴戟的叶和果实均可作为体重管理中的抗肥胖剂。
