Wigati Dyan, Anwar Khoerul, Nugroho Agung Endro
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
STIFAR Yayasan Farmasi, Semarang, Indonesia.
J Evid Based Complementary Altern Med. 2017 Jan;22(1):107-113. doi: 10.1177/2156587216653660. Epub 2016 Jun 16.
The effect of ethanolic extract of Morinda citrifolia leaves and fruit on blood pressure in dexamethasone-induced hypertension rat was evaluated. Total phenolic content of Morinda citrifolia leaves ethanolic extract (MCLEE) and Morinda citrifolia leaves ethanolic extract (MCFEE) was 1.789 ± 0.116 and 1.677 ± 0.051 mg of gallic acid equivalents per gram sample, respectively. Rutin level in MCLEE was 0.92 ± 0.19%, and scopoletin level in MCFEE was 0.46 ± 0.05%. MCLEE, MCFEE, and its extract combination significantly decreased the blood pressure of hypertensive rats. The combination group showed highest hypotensive activity by lowering systolic blood pressure by 16.71 ± 3.95%, diastolic blood pressure by 21.49 ± 7.90%, and mean arterial blood pressure by 19.58% ± 6.35. All extract treatments have not been able to repair or inhibit renal damage caused by dexamethasone induction.
评估了巴戟天叶和果实的乙醇提取物对地塞米松诱导的高血压大鼠血压的影响。巴戟天叶乙醇提取物（MCLEE）和巴戟天果实乙醇提取物（MCFEE）的总酚含量分别为每克样品1.789±0.116和1.677±0.051毫克没食子酸当量。MCLEE中的芦丁含量为0.92±0.19%，MCFEE中的东莨菪素含量为0.46±0.05%。MCLEE、MCFEE及其提取物组合显著降低了高血压大鼠的血压。联合组通过降低收缩压16.71±3.95%、舒张压21.49±7.90%和平均动脉血压19.58%±6.35显示出最高的降压活性。所有提取物处理均未能修复或抑制地塞米松诱导引起的肾损伤。
