Weigert Monika, Gruber Diego, Pernicka Elisabeth, Bauer Peter, Feichtinger Wilfried
Wunschbabyzentrum, Vienna, Austria.
J Assist Reprod Genet. 2009 Jan;26(1):13-7. doi: 10.1007/s10815-008-9278-2. Epub 2008 Nov 20.
To investigate the incidence of Tubal Ectopic Pregnancies (TEP) in IVF-ET patients with respect to the status of the fallopian tubes after a previous TEP.
This retrospective study compares patients undergoing 481 IVF-ET cycles after conservatively or surgically treated TEP(s) with a Control Group (idiopathic or male factor for IVF-ET indication). Medical reports of surgery and/or hysterosalpingograms prior to the IVF cycles classified the status of the fallopian tubes.
12 TEPs (8.95%/Pregnancies (PR)) occurred in the Study Group. In the Control Group one TEP (0.75%/PR; p < 0.001) was found. Smoking increased the probability of TEPs (p = 0.0028) and of pathological pregnancies (abortion, biochemical and ectopic PR; (p = 0.0411)). For statistic evolution logistic regression (PROC GENMOD) and a repeated measure model were applied.
Women with a previous TEP should be informed about the significantly increased risk for a further TEP in IVF-ET treatment, especially if they are smoking.
探讨既往有输卵管异位妊娠（TEP）的体外受精-胚胎移植（IVF-ET）患者中，根据既往TEP后输卵管状况的TEP发生率。
本回顾性研究将481例经保守或手术治疗TEP后接受IVF-ET周期的患者与对照组（因特发性或男性因素而行IVF-ET的患者）进行比较。IVF周期前的手术和/或子宫输卵管造影的医学报告对输卵管状况进行了分类。
研究组发生了12例TEP（8.95%/妊娠（PR））。在对照组中发现1例TEP（0.75%/PR；p<0.001）。吸烟增加了TEP的发生概率（p=0.0028）以及病理妊娠（流产、生化妊娠和异位妊娠PR；（p=0.0411））的发生概率。应用统计进化逻辑回归（PROC GENMOD）和重复测量模型。
既往有TEP的女性应被告知在IVF-ET治疗中再次发生TEP的风险显著增加，尤其是在她们吸烟的情况下。
