从患者和健康携带者中分离出的脑膜炎奈瑟菌菌株释放内毒素的情况。
Endotoxin liberation by strains of N. meningitidis isolated from patients and healthy carriers.
作者信息
Mellado M C, Rodríguez-Contreras R, Fernandez-Crehuet M, Lopez-Gigosos R, Delgado Rodriguez M, Galvez-Vargas R
机构信息
Department of Preventive Medicine, School of Medicine, University of Granada, Spain.
出版信息
Epidemiol Infect. 1991 Apr;106(2):289-95. doi: 10.1017/s0950268800048433.
The main objective of this study was to assess whether the capacity of Neisseria meningitidis to release endotoxin depends upon the type of strain or upon bacterial mass. Endotoxin release was studied in 32 strains isolated from patients with meningococcal infections and in 49 from asymptomatic carriers, using a quantitative test (limulus test with a chromogenic substrate). The results show that the strains from patients release significantly higher amounts of endotoxin than strains from carriers regardless of serogroup and isolation site. No correlation was found between stage of bacterial growth and the amount of endotoxin liberated. These findings suggest that endotoxin liberation is a characteristic of certain strains of N. meningitidis and is not determined simply by bacterial mass.
本研究的主要目的是评估脑膜炎奈瑟菌释放内毒素的能力是否取决于菌株类型或细菌数量。使用定量试验（基于显色底物的鲎试剂法），对从脑膜炎球菌感染患者中分离出的32株菌株以及从无症状携带者中分离出的49株菌株进行了内毒素释放研究。结果表明，无论血清群和分离部位如何，来自患者的菌株释放的内毒素量显著高于来自携带者的菌株。未发现细菌生长阶段与释放的内毒素量之间存在相关性。这些发现表明，内毒素释放是某些脑膜炎奈瑟菌菌株的一个特征，并非简单地由细菌数量决定。
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