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[Hmim]TFA 催化的多组分反应：合成 1,2-二氢喹唑啉衍生物的直接、温和、高效方法。

[Hmim]TFA catalyzed multicomponent reaction: direct, mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives.

机构信息

Department of Chemistry, Faculty of Science, Shahid Beheshti University, GC, Evin, Tehran 1983963113, Iran

出版信息

Mol Divers. 2010 Aug;14(3):507-12. doi: 10.1007/s11030-009-9219-8. Epub 2010 Jan 29.

DOI:10.1007/s11030-009-9219-8
PMID:20111905
Abstract

4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products.

摘要

4-取代螺-1,2-二氢喹唑啉及相关化合物可通过在双功能催化剂-溶剂离子液体[Hmim]TFA 存在下，直接用 2-氨基二苯甲酮、靛红或 1,2-二酮衍生物与乙酸铵反应合成。起始原料的转化率很高，生成了所需的 1,2-二氢喹唑啉产物。

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