Werne Adam, Harris Alon, Moore Danny, BenZion Itay, Siesky Brent
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Surv Ophthalmol. 2008 Nov-Dec;53(6):559-67. doi: 10.1016/j.survophthal.2008.08.021.
Intraocular pressure, a major risk factor for glaucoma, is known to vary throughout the day, yet glaucoma continues to progress in some patients despite it being well controlled. It is important to understand how other glaucomatous risk factors are affected by circadian variations. The purpose of this review is to analyze the literature concerning circadian variations in systemic blood pressure, ocular perfusion pressure, and ocular blood flow and to identify consensus findings regarding their impact on glaucoma. This review suggests that nonphysiologic nocturnal blood pressure dipping and wider circadian fluctuations in ocular perfusion pressure are linked with the development and progression of glaucoma. No consensus concerning circadian variations in ocular blood flow exists in the current literature, and future investigations of nocturnal changes in blood flow and glaucoma progression are required.
眼压是青光眼的一个主要风险因素，已知其在一天中会有所变化，然而，尽管一些患者的眼压得到了良好控制，但青光眼仍在进展。了解其他青光眼风险因素如何受到昼夜节律变化的影响很重要。本综述的目的是分析有关全身血压、眼灌注压和眼血流量昼夜节律变化的文献，并确定关于它们对青光眼影响的共识性发现。本综述表明，非生理性夜间血压下降以及眼灌注压更广泛的昼夜波动与青光眼的发生和进展有关。目前的文献中关于眼血流量的昼夜节律变化尚无共识，需要对血流量的夜间变化和青光眼进展进行进一步研究。
