Ch'ng T W, Chua C Y, Ummi Kalsom M A, Azhany Y, Gong Vhm, Rasool Ahg, Liza-Sharmini A T
Department of Ophthalmology, School of Medical Science, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia; Department of Ophthalmology, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia.
Department of Ophthalmology, Hospital Bukit Mertajam, Bukit Mertajam, Penang, Malaysia.
J Curr Glaucoma Pract. 2021 May-Aug;15(2):78-85. doi: 10.5005/jp-journals-10078-1305.
To establish the association between 12-month inter-visits ocular perfusion pressure (OPP) and severity of glaucoma.
A total of 164 eyes (60 primary open-angle glaucoma, 52 normal-tension glaucoma, and 52 primary angle-closure glaucoma) of 164 patients were analyzed in this prospective cohort study. Patients who demonstrated good compliance to treatment were recruited. The severity of glaucoma was stratified according to the Advanced Glaucoma Intervention Study (AGIS) score based on reliable and reproducible visual field analysis at baseline. OPP was obtained at baseline and a 3-monthly follow-up visit over a 12-month duration. The pattern and fluctuation of mean OPP were studied. Repetitive measure ANOVA and one-way ANOVA were used for statistical analysis.
The inter-visits mean OPP ( = 0.010), systolic OPP ( = 0.020), diastolic OPP ( = 0.010), systolic blood pressure ( = 0.040), and diastolic blood pressure ( = 0.006) showed significant difference with severity of glaucoma. There was no significant difference between mean inter-visits intraocular pressure (IOP) and severity of glaucoma ( = 0.410). The end-stage glaucoma group had the lowest mean OPP and widest inter-visit mean OPP fluctuation. Early and mild glaucoma patients demonstrated higher mean OPP compared with moderate, severe, and end-stage glaucoma.
There is a significant association between OPP and the severity of glaucoma. Balancing blood pressure and IOP is important in optimizing adequate perfusion and prevent further damage to the optic nerve head.
Ch'ng TW, Chua CY, Ummi Kalsom MA, Ocular Perfusion Pressure and Severity of Glaucoma: Is There a Link? J Curr Glaucoma Pract 2021;15(2):78-85.
确定12个月随访期间眼灌注压（OPP）与青光眼严重程度之间的关联。
在这项前瞻性队列研究中，分析了164例患者的164只眼睛（60例原发性开角型青光眼、52例正常眼压性青光眼和52例原发性闭角型青光眼）。招募了治疗依从性良好的患者。根据青光眼高级干预研究（AGIS）评分，基于基线时可靠且可重复的视野分析对青光眼严重程度进行分层。在基线时以及在12个月期间每3个月进行一次随访时获取OPP。研究了平均OPP的模式和波动情况。采用重复测量方差分析和单因素方差分析进行统计分析。
随访期间的平均OPP（P = 0.010）、收缩期OPP（P = 0.020）、舒张期OPP（P = 0.010）、收缩压（P = 0.040）和舒张压（P = 0.006）与青光眼严重程度存在显著差异。随访期间的平均眼压（IOP）与青光眼严重程度之间无显著差异（P = 0.410）。晚期青光眼组的平均OPP最低，随访期间平均OPP波动最大。与中度、重度和晚期青光眼患者相比，早期和轻度青光眼患者的平均OPP更高。
OPP与青光眼严重程度之间存在显著关联。平衡血压和眼压对于优化充足灌注以及预防对视神经乳头的进一步损害非常重要。
Ch'ng TW, Chua CY, Ummi Kalsom MA, 眼灌注压与青光眼严重程度：有联系吗？《当代青光眼实践杂志》2021年；15(2):78 - 85。
