Zhang Ying Lao, Ge Hui Ming, Li Fang, Song Yong Chun, Tan Ren Xiang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, P. R. China, (phone: +86-25-8359-5103; fax: +86-25-8368-6559).
Chem Biodivers. 2008 Nov;5(11):2402-7. doi: 10.1002/cbdv.200890204.
Two new phytotoxic gamma-lactones, pestalotines A and B (1 and 2, resp.), along with 4-oxo-4H-pyran-3-acetic acid (3) and 6-hydroxyramulosin (=3,4,4a,5,6,7-hexahydro-6,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one; 4), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B (1 and 2, resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC(50) values of 1.85 x 10(-4) and 2.50 x 10(-4) M, respectively, comparable to that of 2-(2,4-dichlorophenoxy)acetic acid (0.94 x 10(-4) M) used as a positive control.
从玫瑰竹节虫肠道内的一种拟盘多毛孢属真菌Pestalotiopsis sp. HC02的培养物中分离出两种新的具有植物毒性的γ-内酯，分别为盘多毛孢菌素A和B（分别为1和2），以及4-氧代-4H-吡喃-3-乙酸（3）和6-羟基ramulosin（=3,4,4a,5,6,7-六氢-6,8-二羟基-3-甲基-1H-2-苯并吡喃-1-酮；4）。根据它们的红外光谱、核磁共振光谱和质谱数据阐明了这些新代谢产物的结构。盘多毛孢菌素A和B（分别为1和2）显著抑制稗草的胚根生长，其半数抑制浓度（IC50）值分别为1.85×10⁻⁴和2.50×10⁻⁴ M，与用作阳性对照的2-(2,4-二氯苯氧基)乙酸（0.94×10⁻⁴ M）相当。
