来源于红树林内生真菌的聚酮化合物衍生物。

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany.

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.

Mar Drugs. 2020 Feb 23;18(2):129. doi: 10.3390/md18020129.

Chemical investigation of secondary metabolites from the endophytic fungus led to the isolation of eighteen new polyketide derivatives, pestalotheols I-Q (-) and cytosporins O-W (-), together with eight known analogs (- and -). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher's method was applied to determine the absolute configuration of some compounds. Compound showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC value of 3.0 μM. Furthermore, compounds and showed moderate antibacterial activity against drug-resistant (ATCC BAA-1605) in combination with sublethal colistin concentrations.

从内生真菌中分离得到的次级代谢产物的化学研究导致了十八种新的聚酮衍生物，pestalotheols I-Q(-) 和 cytosporins O-W(-)，以及八种已知类似物(-和-)的分离。新化合物的结构通过高分辨质谱和 1D 和 2D NMR 数据以及与文献数据的比较来阐明。改良的 Mosher 法被应用于确定一些化合物的绝对构型。化合物对小鼠淋巴瘤细胞系 L5178Y 具有显著的细胞毒性，IC 值为 3.0 μM。此外，化合物和与亚致死浓度的多粘菌素联合使用时对耐药性 (ATCC BAA-1605) 表现出中等的抗菌活性。