伊朗组织库中人体T淋巴细胞病毒（HTLV）在组织捐赠者中的血清阳性率。

Seroprevalence of human T lymphtropic virus (HTLV) among tissue donors in Iranian tissue bank.

作者信息

Arjmand Babak, Aghayan Seyed Hamidreza, Goodarzi Parisa, Farzanehkhah Mohammad, Mortazavi Seyed Mohamadjavad, Niknam Mohamad Hossein, Jafarian Ali, Arjmand Farzin, Jebelly far Soheyla

机构信息

Iranian Tissue Bank Research and Preparation Center & Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran.

出版信息

Cell Tissue Bank. 2009 Aug;10(3):247-52. doi: 10.1007/s10561-008-9117-9. Epub 2008 Nov 27.

DOI:10.1007/s10561-008-9117-9

PMID:19037751

Abstract

Iranian Tissue Bank prepares a wide range of human tissue homografts such as; heart valve, bone, skin, amniotic membrane and other tissues for different clinical applications. The purpose of this study was to determine the seroprevalence of HTLV in tissue donors. About 1,548 tissue donors were studied during a 5-years period by ELISA assays. HTLV(1,2)-antibodies were tested for all of donors with other tests upon American Association of Tissue Banks (AATB) standards. About 25 (1.61%) out of 1,548 tissue donors were HTLV positive that 17 donors were male and 8 were female (female/male ratio was approximately 47%). Regarding to the prevalence of HTLV among tissue donors and importance of cell and tissue safety and quality assurance, we recommend that all blood, cell and tissue banks should be involved both routine serological methods and other complementary tests such as polymerase chain reaction (PCR) for diagnosis of HTLV.

摘要

伊朗组织库为不同的临床应用准备了多种人体组织同种移植物，如心脏瓣膜、骨骼、皮肤、羊膜和其他组织。本研究的目的是确定组织供体中人类T细胞白血病病毒（HTLV）的血清流行率。在5年期间，通过酶联免疫吸附测定（ELISA）对约1548名组织供体进行了研究。根据美国组织库协会（AATB）的标准，对所有供体进行了HTLV（1,2）抗体检测及其他检测。在1548名组织供体中，约25名（1.61%）HTLV呈阳性，其中17名供体为男性，8名供体为女性（女性/男性比例约为47%）。鉴于组织供体中HTLV的流行情况以及细胞和组织安全性及质量保证的重要性，我们建议所有血液、细胞和组织库应采用常规血清学方法以及其他补充检测，如聚合酶链反应（PCR）来诊断HTLV。