Li Chun-Ying, Xu Hong-De, Zhao Bing-Tian, Chang Hyo-Ihl, Rhee Hae-Ik
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea.
Alcohol. 2008 Dec;42(8):683-7. doi: 10.1016/j.alcohol.2008.08.009.
This study investigated the in vivo protective effect of cyanidin 3-glucoside (C3G) against ethanol-induced gastric lesions in rats. The experimental rats were treated with 80% ethanol after pretreatment with various doses of C3G (4 and 8 mg/kg of body weight), and the control rats received only 80% ethanol. Oral pretreatment with C3G significantly inhibited the formation of ethanol-induced gastric lesions and the elevation of the lipid peroxide level. In addition, pretreatment with C3G significantly increased the level of glutathione and the activities of radical scavenging enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, in gastric tissues. These results suggest that the gastroprotective effect of C3G removes the ethanol-induced lipid peroxides and free radicals and that it may offer a potential remedy for the treatment of gastric lesions.
本研究调查了花青素3 - 葡萄糖苷（C3G）对大鼠乙醇诱导的胃损伤的体内保护作用。在用不同剂量的C3G（4和8毫克/千克体重）预处理后，给实验大鼠注射80%乙醇，而对照大鼠仅接受80%乙醇。C3G口服预处理显著抑制了乙醇诱导的胃损伤的形成以及脂质过氧化物水平的升高。此外，C3G预处理显著提高了胃组织中谷胱甘肽水平以及超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等自由基清除酶的活性。这些结果表明，C3G的胃保护作用可清除乙醇诱导的脂质过氧化物和自由基，并且它可能为胃损伤的治疗提供一种潜在的补救方法。
