Baskerville A, Lloyd G
J Med Microbiol. 1977 Feb;10(1):139-44. doi: 10.1099/00222615-10-1-139.
Monkeys were infected intranasally with Herpesvirus suis. After an incubation period of 7 to 13 days the animals became acutely ill and rapidly died. Clinical signs included salivation, incoordination, ataxia and epileptiform convulsions, but not pruritus. Histopathological changes were confined to the central nervous system, and consisted of destruction of neurones with the formation of intranuclear inclusion bodies, gliosis and perivascular cuffing. Virus was isolated from the brain and spinal cord in the later stages of the illness but neutralising antibodies were not detected in serum. The distribution of lesions indicated direct spread of virus from the inoculation site along cranial nerves to the brain.
将猪疱疹病毒经鼻内接种感染猴子。经过7至13天的潜伏期后，动物出现急性疾病并迅速死亡。临床症状包括流涎、共济失调、运动失调和癫痫样惊厥，但无瘙痒症状。组织病理学变化局限于中枢神经系统，表现为神经元破坏并形成核内包涵体、胶质细胞增生和血管周围套袖状浸润。在疾病后期从脑和脊髓中分离出病毒，但血清中未检测到中和抗体。病变分布表明病毒从接种部位沿颅神经直接传播至脑。
