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吸入性类固醇的意外副作用:一例报告

Unexpected side-effects of inhaled steroids: a case report.

作者信息

Priftis K, Everard M L, Milner A D

机构信息

Children's Respiratory Unit, University Hospital, Queen's Medical Centre, Nottingham, UK.

出版信息

Eur J Pediatr. 1991 Apr;150(6):448-9. doi: 10.1007/BF02093730.

DOI:10.1007/BF02093730
PMID:1904030
Abstract

An asthmatic child is presented who developed a cushingoid appearance with evidence of adrenal suppression and growth impairment while on low dose inhaled topical steroids. When the inhaled steroids were replaced by inhaled sodium cromoglycate his adrenal function recovered while his appearance and growth returned to normal. This report indicates that there are some children who are at risk of developing side-effects on doses of inhaled topical steroids normally considered to be entirely safe.

摘要

报告了一名哮喘儿童,该儿童在使用低剂量吸入性局部类固醇时出现库欣样外观,并有肾上腺抑制和生长障碍的证据。当吸入性类固醇被吸入色甘酸钠替代后,其肾上腺功能恢复,外观和生长也恢复正常。本报告表明,有些儿童在使用通常认为完全安全剂量的吸入性局部类固醇时,有发生副作用的风险。

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Unexpected side-effects of inhaled steroids: a case report.吸入性类固醇的意外副作用:一例报告
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2
Cushing's syndrome from an inhaled glucocorticoid.吸入性糖皮质激素所致库欣综合征
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Beclomethasone dipropionate inhaler: a review of its pharmacology, therapeutic value and adverse effects. I: Asthma.二丙酸倍氯米松吸入器:其药理学、治疗价值及不良反应综述。I:哮喘
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本文引用的文献

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Development of new glucocorticosteroids with a very high ratio between topical and systemic activities.
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Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.吸入性丙酸倍氯米松对哮喘患儿下丘脑-垂体-肾上腺轴功能的影响。
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Biotransformation of the topical glucocorticoids budesonide and beclomethasone 17 alpha,21-dipropionate in human liver and lung homogenate.局部用糖皮质激素布地奈德和倍氯米松 17α,21 - 二丙酸酯在人肝和肺匀浆中的生物转化。
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Adrenal function and high dose inhaled corticosteroids for asthma.肾上腺功能与高剂量吸入性糖皮质激素治疗哮喘
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Inhaled corticosteroids in children. Is there a 'safe' dosage?
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Management of carcinomas of the upper gastrointestinal tract.上消化道癌的管理
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Inhaled corticosteroid therapy in children: an assessment of the potential for side effects.儿童吸入性糖皮质激素治疗:副作用可能性评估
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Adrenocortical function in children on high-dose steroid aerosol therapy. Results of serum cortisol, ACTH stimulation test and 24 hour urinary free cortical excretion.接受高剂量类固醇气雾剂治疗儿童的肾上腺皮质功能。血清皮质醇、促肾上腺皮质激素刺激试验及24小时尿游离皮质醇排泄结果。
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Overt glucocorticoid excess due to inhaled corticosteroid therapy.吸入性糖皮质激素治疗导致的明显糖皮质激素过量。
Pediatrics. 1988 Mar;81(3):452-5.
6
Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide.
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7
Nocturnal adrenal suppression in asthmatic children taking inhaled beclomethasone dipropionate.吸入丙酸倍氯米松的哮喘儿童的夜间肾上腺抑制
Lancet. 1986 Apr 26;1(8487):942-4. doi: 10.1016/s0140-6736(86)91045-7.
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Adrenal function in asthma.哮喘中的肾上腺功能。
Arch Dis Child. 1990 Aug;65(8):838-40. doi: 10.1136/adc.65.8.838.
9
A three- to five-year follow-up of the use of the aerosol steroid, beclomethasone dipropionate, in childhood asthma.丙酸倍氯米松气雾剂用于儿童哮喘的三至五年随访
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