聚合物载体：几何形状在药物递送中的作用。
Polymeric carriers: role of geometry in drug delivery.
作者信息
Simone Eric A, Dziubla Thomas D, Muzykantov Vladimir R
机构信息
University of Pennsylvania, Department of Bioengineering, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA.
出版信息
Expert Opin Drug Deliv. 2008 Dec;5(12):1283-300. doi: 10.1517/17425240802567846.
The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.
合成纳米结构的独特性质使其有望作为药物递送载体应用于多种领域，在生物相容性、药代动力学、靶向性和药物控释方面具有优势。从历史上看，更传统的药物递送系统主要关注球形载体。然而，由于新型制剂策略的出现，现在人们对非球形载体（如细长或丝状形态）的研究兴趣日益浓厚。这些超分子结构独特的物理化学性质使其作为药物递送系统具有明显优势。特别是，最近在细胞培养和实验动物中的研究结果表明，对给定几何形状（尺寸和形状）的载体进行合理设计，可以前所未有的方式控制其在循环中的寿命以及靶向选定的细胞和亚细胞位置。本文综述了非球形药物递送系统的药物递送方面，包括材料选择与制剂、药物负载与释放、生物相容性、循环行为、靶向性和亚细胞定位。
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