Hyung Kyeong Eun, Kim Soo Jeong, Jang Ye Won, Lee Da Kyoung, Hyun Kee Hyeob, Moon Byoung Seok, Kim Bongjoon, Ahn Heeyoon, Park So-Young, Sohn Uy Dong, Park Eon Sub, Hwang Kwang Woo
College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
CJ CheilJedang Corporation, Suwon 16495, Korea.
Korean J Physiol Pharmacol. 2017 May;21(3):335-343. doi: 10.4196/kjpp.2017.21.3.335. Epub 2017 Apr 21.
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-γ, and IL-6,which were stimulated by house dust mite extracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC/Nga mice after onset of the disease by altering immune cell activation. The strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD.
特应性皮炎（AD）是一种伴有水肿和出血等症状的炎症性皮肤病。泡菜是一种由多种益生菌组成的传统韩国发酵食品。在本研究中，对从泡菜中分离出的CJLP55在AD诱导小鼠中的治疗效果进行了研究。口服菌株CJLP55可抑制AD症状和高血清IgE水平。给予CJLP55可减少表皮厚度、肥大细胞和嗜酸性粒细胞向皮肤病变部位的浸润、腋窝淋巴结肿大以及腋窝淋巴结中细胞数量的增加。CJLP55治疗可降低腋窝淋巴结细胞中由屋尘螨提取物刺激产生的2型细胞因子的产生，如白细胞介素（IL）-4、IL-5、IL-10、IL-12、干扰素（IFN）-γ和IL-6。口服CJLP55在疾病发作后通过改变免疫细胞激活，对NC/Nga小鼠屋尘螨诱导的AD表现出治疗效果。从泡菜中分离出的菌株CJLP55可抑制AD。我们的结果表明其可能作为AD管理的潜在候选物。
