从成年恒河猴成纤维细胞中诱导生成多能干细胞。
Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.
作者信息
Liu Haisong, Zhu Fangfang, Yong Jun, Zhang Pengbo, Hou Pingping, Li Honggang, Jiang Wei, Cai Jun, Liu Meng, Cui Kai, Qu Xiuxia, Xiang Tingting, Lu Danyu, Chi Xiaochun, Gao Ge, Ji Weizhi, Ding Mingxiao, Deng Hongkui
出版信息
Cell Stem Cell. 2008 Dec 4;3(6):587-90. doi: 10.1016/j.stem.2008.10.014.
PMID:19041774
Abstract
Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in mouse and human. However, direct reprogramming in other species has not been reported. Here, we generated monkey iPS cells by retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC.
摘要
通过向小鼠和人类体细胞转导几种转录因子可诱导产生诱导多能干细胞（iPS细胞）。然而，尚未见在其他物种中直接重编程的报道。在此，我们通过逆转录病毒介导导入猴转录因子OCT4、SOX2、KLF4和c-MYC，成功产生了猴iPS细胞。
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