Guangzhou First Municipal People's Hospital, Affiliated Guangzhou Medical College, #1 Pan Fu Road, Guangzhou 510180, China.
Pathol Oncol Res. 2009 Sep;15(3):369-74. doi: 10.1007/s12253-008-9131-z.
Extracellular matrix metalloproteinase inducer (EMMPRIN, also named as CD147) is a multifunctional membrane glycoprotein over-expressed in many kinds of human solid tumors. It has been demonstrated to be involved in tumor invasion and angiogenesis. The aim of this study was to analyze the clinicopathological characteristics of the expression of CD147 in human prostate cancer (PCa), and to evaluate its clinical significance in the histologic classification and prognosis of PCa. CD147 protein expression in paraffin-embedded specimens gathered from 62 cases of PCa and 30 cases of benign prostatic hyperplasia (BPH) were detected by the method of immunohistochemistry. The association of CD147 protein expression with the clinicopathological characteristics and with the prognosis of PCa was subsequently assessed. CD147 expression were positively expressed in 51/62 (82.3%) of PCa and 4/30 (13.3%) of BPH cases, respectively. The positive expression rate of CD147 in PCa tissues was significantly higher than that in BPH. The positive expression of CD147 was dramatically associated with TNM grade (p < 0.001), the depth of the prostatic wall invasion (p = 0.008), GLEASON Score (p = 0.001) and Histologic grade (p = 0.001). The patients with CD147 expression were associated with a poor prognosis of PCa (p = 0.01) and the survival rate of the patients with a strong positive expression of CD147 was the lowest (p = 0.01). The results suggest that the expression of CD147 may be an important feature of PCa and the detection of its expression may benefit us in the prediction of the prognosis of PCa.
细胞外基质金属蛋白酶诱导因子（EMMPRIN，也称为 CD147）是一种在多种人类实体瘤中过度表达的多功能膜糖蛋白。它已被证明参与肿瘤侵袭和血管生成。本研究旨在分析 CD147 在人前列腺癌（PCa）中的表达的临床病理特征，并评估其在 PCa 的组织学分类和预后中的临床意义。采用免疫组织化学方法检测 62 例 PCa 和 30 例良性前列腺增生（BPH）石蜡包埋标本中 CD147 蛋白的表达。随后评估 CD147 蛋白表达与 PCa 的临床病理特征和预后的关系。在 62 例 PCa 中，CD147 表达呈阳性表达的有 51/62（82.3%），30 例 BPH 中有 4/30（13.3%）。PCa 组织中 CD147 的阳性表达率明显高于 BPH。CD147 的阳性表达与 TNM 分级（p < 0.001）、前列腺壁浸润深度（p = 0.008）、GLEASON 评分（p = 0.001）和组织学分级（p = 0.001）显著相关。CD147 表达的患者与 PCa 的不良预后相关（p = 0.01），CD147 强阳性表达患者的生存率最低（p = 0.01）。结果表明，CD147 的表达可能是 PCa 的一个重要特征，检测其表达可能有助于预测 PCa 的预后。
