Cross J Helen, Neal Elizabeth G
UCL-Institute of Child Health, London, UK.
Epilepsia. 2008 Nov;49 Suppl 8:6-10. doi: 10.1111/j.1528-1167.2008.01822.x.
The ketogenic diet (KD) has been used in the treatment of epilepsy for almost 100 years. Several cohort studies have emphasized its possible benefit, although use became less at the introduction of anticonvulsant medication. However, the KD has regained recognition over the past 15 years. Resources remain scarce and its availability for children may be limited. One argument has been the lack of evidence from suitably designed trials. Systematic reviews and meta-analyses have revealed that studies are limited to class 3 and 4 data. A recently published randomized controlled trial has shown that the benefit of the KD is equivalent to any of the new anticonvulsant medications, emphasizing the need for more resources to ensure greater diet availability.
生酮饮食（KD）用于治疗癫痫已有近100年历史。多项队列研究强调了其可能的益处，尽管在抗惊厥药物问世后其使用有所减少。然而，在过去15年中，生酮饮食重新获得了认可。相关资源仍然稀缺，儿童使用该饮食的机会可能有限。一个原因是缺乏设计合理的试验证据。系统评价和荟萃分析表明，相关研究仅限于3级和4级数据。最近发表的一项随机对照试验表明，生酮饮食的益处等同于任何一种新型抗惊厥药物，这凸显了需要更多资源以确保该饮食有更广泛的可及性。
