在小鼠和大鼠大脑中，胶质纤维酸性蛋白的浓度随年龄增长而增加。
The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain.
作者信息
O'Callaghan J P, Miller D B
机构信息
Neurotoxicology Division (MD-74B), U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
出版信息
Neurobiol Aging. 1991 Mar-Apr;12(2):171-4. doi: 10.1016/0197-4580(91)90057-q.
The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 (Mr 200 kilodaltons), were not altered by aging in any region of the mouse or rat brain. Brains of aged rats, but not mice, showed a decrease in beta-tubulin. The data suggest that astrocytic hypertrophy observed with aging involves an accumulation of glial filaments.
研究了衰老在星形胶质细胞蛋白——胶质纤维酸性蛋白（GFAP）表达中的作用。在小鼠和大鼠中，GFAP的浓度随衰老在整个大脑中升高。在这两个物种的纹状体中观察到最大的升高（2倍）。神经元特异性蛋白，突触素I和神经丝200（分子量200千道尔顿），在小鼠或大鼠大脑的任何区域都不会因衰老而改变。老年大鼠而非小鼠的大脑中β-微管蛋白减少。数据表明，衰老时观察到的星形胶质细胞肥大涉及胶质纤维的积累。
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