Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Göteborg University, 41345, Göteborg, Sweden.
Int Orthop. 2009 Dec;33(6):1495-500. doi: 10.1007/s00264-008-0699-4. Epub 2008 Dec 3.
We performed repeated dual-energy X-ray absorptiometry (DEXA) measurements over five years in a homogeneous patient population to study the effect of a cemented stem on proximal femoral bone remodelling. Data from 88 patients (88 hips) implanted with total hip arthroplasty (THA) prostheses were extracted from three randomised studies. Femoral bone mineral density (BMD) was measured using a Lunar DPX-IQ densitometer for five years postoperatively. At one year the BMD changes had decreased between -2.0% [region of interest (ROI) 1] and -11.5% (ROI 7). During the follow-up period the BMD initially increased during the second year and thereafter decreased again in ROIs 5, 6 and 7. The loss of BMD at five years was more pronounced in region 7 (12.9%) and decreased with increasing age, total hip replacement (THR) on the right side and decreasing weight of the patient. We found that after the initial phase of early bone loss a period of recovery follows. Thereafter the BMD decreases again, which probably reflects the normal ageing of bone after uncomplicated cemented THA.
我们在五年内对同质患者人群进行了多次双能 X 射线吸收法(DEXA)测量,以研究骨水泥型股骨柄对股骨近端骨重塑的影响。从三项随机研究中提取了 88 名接受全髋关节置换术(THA)假体植入的患者(88 髋)的数据。术后五年使用 Lunar DPX-IQ 密度仪测量股骨骨密度(BMD)。一年时,ROI1 处的 BMD 变化范围为-2.0%,ROI7 处的 BMD 变化范围为-11.5%。在随访期间,ROI5、6 和 7 中的 BMD 最初在第二年增加,然后再次减少。五年时,ROI7(12.9%)处的 BMD 丢失更为明显,并随年龄、右侧 THR 和患者体重的增加而减少。我们发现,在早期骨丢失的初始阶段之后,会出现一个恢复阶段。此后,BMD 再次下降,这可能反映了骨在接受无并发症骨水泥型 THA 后的正常老化。