多壁碳纳米管对水生物种的影响。
Impact of multi-walled carbon nanotubes on aquatic species.
作者信息
Asharani P V, Serina N G B, Nurmawati M H, Wu Y L, Gong Z, Valiyaveettil S
机构信息
Department of Chemistry, Faculty of Science, 3 Science Drive 3, National University of Singapore, Singapore 117543.
出版信息
J Nanosci Nanotechnol. 2008 Jul;8(7):3603-9. doi: 10.1166/jnn.2008.432.
To understand the environmental impacts of carbon nanotubes (CNTs), the toxicity study was carried out with water-soluble multi-walled carbon nanotubes (MWCNTs) using zebrafish (Danio rerio) as a model system. Zebrafish embryos were treated with different concentrations of MWCNTs. Teratogenic effects were evaluated through changes in embryonic development after 24 hours post-fertilization (hpf), 48 hpf and 72 hpf. No observable effect concentration (NOEC) was at 40 microg/mL. Lowest effect concentration (LOEC) of MWCNTs which caused significant phenotypic defects in zebrafish embryo was 60 microg/mL. At concentration above 60 microg/mL, slimy mucus like coating was observed around the embryo. At high concentrations, MWCNTs was found to be involved in the apoptosis, delayed hatching and formation of abnormal spinal chords. Thus, the toxicity of multi-walled carbon nanotubes is concentration dependent.
为了解碳纳米管（CNTs）对环境的影响，以斑马鱼（Danio rerio）为模型系统，对水溶性多壁碳纳米管（MWCNTs）进行了毒性研究。用不同浓度的MWCNTs处理斑马鱼胚胎。通过受精后24小时（hpf）、48 hpf和72 hpf后胚胎发育的变化来评估致畸作用。无可观察效应浓度（NOEC）为40微克/毫升。在斑马鱼胚胎中引起显著表型缺陷的MWCNTs的最低效应浓度（LOEC）为60微克/毫升。在浓度高于60微克/毫升时，在胚胎周围观察到黏液样涂层。在高浓度下，发现MWCNTs参与细胞凋亡、孵化延迟和异常脊髓的形成。因此，多壁碳纳米管的毒性具有浓度依赖性。
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