Dixena Bhupendra, Madhariya Rashmi, Panday Anupama, Ram Alpana, Jain Akhlesh K
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, (C.G.) 495009, India.
Curr Drug Deliv. 2025;22(2):160-180. doi: 10.2174/0115672018272012231213100535.
Transdermal drug delivery systems (TDDS) offer several advantages over traditional methods such as injections and oral administration. These advantages include preventing first-pass metabolism, providing consistent and sustained activity, reducing side effects, enabling the use of short half-life drugs, improving physiological response, and enhancing patient convenience. However, the permeability of skin poses a challenge for TDDS, as it is impermeable to large molecules and hydrophilic drugs but permeable to small molecules and lipophilic drug. To overcome this barrier, researchers have investigated vesicular systems, such as transfersomes, liposomes, niosomes, and ethosomes. Among these vesicular systems, transfersomes are particularly promising for noninvasive drug administration due to their deformability and flexible membrane. They have been extensively studied for delivering anticancer drugs, insulin, corticosteroids, herbal medicines, and NSAIDs through the skin. Transfersomes have demonstrated efficacy in treating skin cancer, improving insulin delivery, enhancing site-specific corticosteroid delivery, and increasing the permeation and therapeutic effects of herbal medicines. They have also been effective in delivering pain relief with minimal side effects using NSAIDs and opioids. Transfersomes have been used for transdermal immunization and targeted drug delivery, offering site-specific release and minimizing adverse effects. Overall, transfersomes are a promising approach for transdermal drug delivery in various therapeutic applications.
The aim of the present review is to discuss the various advantages and limitations of transfersomes and their mechanism to penetration across the skin, as well as their application for the delivery of various drugs like anticancer, antidiabetic, NSAIDs, herbal drugs, and transdermal immunization.
Data we searched from PubMed, Google Scholar, and ScienceDirect.
In this review, we have explored the various methods of preparation of transfersomes and their application for the delivery of various drugs like anticancer, antidiabetic, NSAIDs, herbal drugs, and transdermal immunization.
In comparison to other vesicular systems, transfersomes are more flexible, have greater skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal drug delivery. The developed transfersomal gel could be used to improve medicine delivery through the skin.
与注射和口服等传统给药方法相比，经皮给药系统（TDDS）具有诸多优势。这些优势包括避免首过代谢、提供持续稳定的活性、减少副作用、能够使用半衰期短的药物、改善生理反应以及提高患者便利性。然而，皮肤的渗透性给经皮给药系统带来了挑战，因为皮肤对大分子和亲水性药物不渗透，但对小分子和脂溶性药物渗透。为克服这一障碍，研究人员研究了囊泡系统，如传递体、脂质体、非离子型脂质体和醇质体。在这些囊泡系统中，传递体因其可变形性和柔性膜而在无创给药方面特别有前景。它们已被广泛研究用于通过皮肤递送抗癌药物、胰岛素、皮质类固醇、草药和非甾体抗炎药。传递体在治疗皮肤癌、改善胰岛素递送、增强皮质类固醇的靶向递送以及提高草药的渗透和治疗效果方面已显示出疗效。它们还通过使用非甾体抗炎药和阿片类药物以最小的副作用有效缓解疼痛。传递体已用于经皮免疫和靶向给药，实现位点特异性释放并将不良反应降至最低。总体而言，传递体是各种治疗应用中经皮给药的一种有前景的方法。
本综述的目的是讨论传递体的各种优势和局限性、其穿透皮肤的机制，以及它们在递送抗癌、抗糖尿病、非甾体抗炎药、草药等各种药物和经皮免疫方面的应用。
我们从PubMed、谷歌学术和科学Direct数据库检索数据。
在本综述中，我们探讨了传递体的各种制备方法及其在递送抗癌、抗糖尿病、非甾体抗炎药、草药等各种药物和经皮免疫方面的应用。
与其他囊泡系统相比，传递体更具柔性，具有更强的皮肤穿透能力，能够运输全身用药，且更稳定。传递体能够递送亲水性和疏水性药物，使其适用于经皮给药。所开发的传递体凝胶可用于改善药物经皮递送。
