Askew D J, Silverman G A
UPMC Newborn Medicine Program, Children's Hospital of Pittsburgh and Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
J Perinatol. 2008 Dec;28 Suppl 3(Suppl 3):S127-35. doi: 10.1038/jp.2008.150.
An imbalance between peptidases and their inhibitors leads to pulmonary disease. Imbalances occur in the adult and the neonate at risk for a specific set of lung pathologies. Serpins (serine peptidase inhibitors) make up the major source of antipeptidase activity in the lung. The purpose of this review is to describe the serpin mechanism of inhibition, their roles in the normal and pathological lung and their potential as therapeutic agents.
肽酶与其抑制剂之间的失衡会导致肺部疾病。在有特定肺部病理风险的成年人和新生儿中都会出现失衡。丝氨酸蛋白酶抑制剂（Serpins）是肺部抗肽酶活性的主要来源。本综述的目的是描述丝氨酸蛋白酶抑制剂的抑制机制、它们在正常和病理肺部中的作用以及它们作为治疗药物的潜力。
