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基于吡啶的镧系元素配合物:迈向兼具近红外发光和磁共振成像报告功能的双功能试剂。

Pyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters.

作者信息

Pellegatti Laurent, Zhang Jian, Drahos Bohuslav, Villette Sandrine, Suzenet Franck, Guillaumet Gérald, Petoud Stéphane, Tóth Eva

机构信息

Centre de Biophysique Moléculaire, CNRS, 45071 Orléans, France.

出版信息

Chem Commun (Camb). 2008 Dec 28(48):6591-3. doi: 10.1039/b817343e. Epub 2008 Nov 12.

DOI:10.1039/b817343e
PMID:19057789
Abstract

We report two prototype Ln(3+) complexes that address requirements for both MRI and luminescence imaging and we demonstrate that the presence of two H(2)O molecules bound to the Ln(3+), beneficial for MRI applications of the Gd(3+) analogue, is not a major limitation for the development of NIR luminescent agents.

摘要

我们报道了两种满足磁共振成像(MRI)和发光成像要求的Ln(3+)配合物原型,并证明与Ln(3+)结合的两个H₂O分子的存在,虽然对Gd(3+)类似物的MRI应用有益,但并非近红外发光剂开发的主要限制因素。

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