外周血管疾病患者中显著无症状性颈动脉疾病的患病率：一项荟萃分析。

Prevalence of significant asymptomatic carotid artery disease in patients with peripheral vascular disease: a meta-analysis.

作者信息

Ahmed B, Al-Khaffaf H

机构信息

East Lancashire Hospitals NHS Trust, General/Vascular Surgery, Burnley General Hospital, Casterton Avenue, Burnley, Lancashire BB10 2PQ, United Kingdom.

出版信息

Eur J Vasc Endovasc Surg. 2009 Mar;37(3):262-71. doi: 10.1016/j.ejvs.2008.10.017. Epub 2008 Dec 6.

DOI:10.1016/j.ejvs.2008.10.017

PMID:19058982

Abstract

OBJECTIVES

To determine the prevalence of asymptomatic carotid artery stenosis (ACAS) in patients with peripheral vascular disease (PVD).

METHODS

Literature search was carried out through Pubmed, Medline and Cochrane library. Prospective studies published on prevalence of significant carotid stenosis in patients with PVD and used a duplex scan for screenings were included.

RESULTS

Nineteen studies with a total of 4573 patients were included. A prevalence of 28% (fixed effect model) and 25% (random effect model) was seen for >50% stenosis, and 14% (in both fixed and random effect models) for 70% stenosis. Significant statistical heterogeneity existed between studies (I(2)=82.7%, >50% group) (I(2)=77.5%, >70% group). Larger studies revealed a higher prevalence of carotid stenosis.

CONCLUSION

High prevalence of ACAS exists in patients with PVD. A large multi centre prospective study may help to combat heterogeneity and identify subgroups of PVD patients with higher prevalence. Clinicians who believe in the benefits of carotid endarterectomy for asymptomatic carotid stenosis would gain a greater yield by targeting this group for routine screening rather than a healthy population.

摘要

目的

确定外周血管疾病（PVD）患者中无症状性颈动脉狭窄（ACAS）的患病率。

方法

通过PubMed、Medline和Cochrane图书馆进行文献检索。纳入发表的关于PVD患者中显著颈动脉狭窄患病率且使用双功超声扫描进行筛查的前瞻性研究。

结果

纳入19项研究，共4573例患者。狭窄程度>50%时，固定效应模型患病率为28%，随机效应模型患病率为25%；狭窄程度为70%时，固定效应模型和随机效应模型的患病率均为14%。各研究间存在显著的统计学异质性（狭窄程度>50%组I(2)=82.7%；狭窄程度>70%组I(2)=77.5%）。规模较大的研究显示颈动脉狭窄患病率较高。