鹅去氧胆酸盐是艰难梭菌孢子萌发的抑制剂。
Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.
作者信息
Sorg Joseph A, Sonenshein Abraham L
机构信息
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
出版信息
J Bacteriol. 2009 Feb;191(3):1115-7. doi: 10.1128/JB.01260-08. Epub 2008 Dec 5.
Abstract
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.
摘要
一些作为胆汁正常成分的胆酸盐衍生物可与甘氨酸共同作用，诱导艰难梭菌孢子萌发，但至少有一种胆汁成分——鹅去氧胆酸盐不会诱导孢子萌发。在此我们表明，鹅去氧胆酸盐可抑制艰难梭菌孢子对胆酸盐和牛磺胆酸盐的萌发反应。
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