Doyon Julien, Bellec Pierre, Amsel Rhonda, Penhune Virginia, Monchi Oury, Carrier Julie, Lehéricy Stéphane, Benali Habib
Functional NeuroImaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada.
Behav Brain Res. 2009 Apr 12;199(1):61-75. doi: 10.1016/j.bbr.2008.11.012. Epub 2008 Nov 17.
This review discusses the cerebral plasticity, and the role of the cortico-striatal system in particular, observed as one is learning or planning to execute a newly learned motor behavior up to when the skill is consolidated or has become highly automatized. A special emphasis is given to imaging work describing the neural substrate mediating motor sequence learning and motor adaptation paradigms. These results are then put into a plausible neurobiological model of motor skill learning, which proposes an integrated view of the brain plasticity mediating this form of memory at different stages of the acquisition process.
本综述讨论了大脑可塑性，尤其是皮质-纹状体系统在个体学习或计划执行新学运动行为直至技能巩固或高度自动化过程中所观察到的作用。特别强调了描述介导运动序列学习和运动适应范式的神经基质的成像研究。然后将这些结果纳入一个合理的运动技能学习神经生物学模型，该模型提出了在习得过程不同阶段介导这种记忆形式的大脑可塑性的综合观点。
