Ullah Mohd Fahad, Aatif Mohammad
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP 202002, India.
Cancer Treat Rev. 2009 May;35(3):193-200. doi: 10.1016/j.ctrv.2008.10.004. Epub 2008 Dec 4.
Diagnostic detection and measurement of cancer disease progression are essential elements for successful cancer disease management. The early stages of cancer development carry the maximum potential for therapeutic interventions. However, these stages are often asymptomatic, leading to delayed diagnosis at the very advanced stages when effective treatments are unavailing. The application of biomarkers to cancer is leading the way because of the unique association of genomic changes in cancer cells with the disease process. They have the potential to not only help identify who will develop cancer but also to predict as to when the event is most likely to occur. In recent years, there has been an enormous effort to develop specific and sensitive biomarkers for precise and accurate screening, diagnosis, prognosis and monitoring of high risk cancer to assist with therapeutic decisions. The present article is a brief review of the emerging trends in the development of biomarkers for early detection and precise evaluation of cancer disease.
癌症疾病进展的诊断检测和测量是成功管理癌症疾病的关键要素。癌症发展的早期阶段具有最大的治疗干预潜力。然而，这些阶段通常没有症状，导致在非常晚期才被诊断出来，而此时有效的治疗方法已无济于事。生物标志物在癌症中的应用正引领着潮流，因为癌细胞中的基因组变化与疾病进程有着独特的关联。它们不仅有可能帮助识别谁会患癌症，还能预测这一事件最有可能在何时发生。近年来，人们付出了巨大努力来开发特异性和敏感性高的生物标志物，用于对高危癌症进行精确准确的筛查、诊断、预后评估和监测，以辅助治疗决策。本文简要综述了用于癌症疾病早期检测和精确评估的生物标志物开发的新趋势。
