孕妇及脐带血中有机氯农药水平：与早产的关联。
Maternal and cord blood levels of organochlorine pesticides: association with preterm labor.
作者信息
Pathak Rahul, Ahmed Rafat S, Tripathi A K, Guleria Kiran, Sharma C S, Makhijani S D, Banerjee B D
机构信息
Department of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India.
出版信息
Clin Biochem. 2009 May;42(7-8):746-9. doi: 10.1016/j.clinbiochem.2008.11.007. Epub 2008 Dec 3.
OBJECTIVES
Organochlorine pesticides (OCPs) have been reported to cause adverse reproductive outcomes. Hence, the present study was conducted to estimate and compare the levels of OCPs in maternal and cord blood of preterm labor and full term labor cases as well as assess their role in preterm delivery.
DESIGN AND METHODS
23 cases each of preterm labor and full term labor were included in the study. Maternal and cord blood OCP levels were determined by using a GC-MS equipped with an electron capture detector.
RESULTS
Maternal and cord blood levels of alpha-HCH, beta-HCH, gamma-HCH, total-HCH, p,p'DDE and p,p'DDT were found higher in preterm labor than full term labor cases. However, a statistically significant relation was observed between preterm birth and beta-HCH levels only.
CONCLUSIONS
Higher blood levels of beta-HCH may be associated with risk of preterm labor.
目的
据报道，有机氯农药（OCPs）会导致不良生殖结局。因此，本研究旨在估计并比较早产和足月产病例的母血和脐血中OCPs的水平，并评估它们在早产中的作用。
设计与方法
本研究纳入了23例早产病例和23例足月产病例。使用配备电子捕获检测器的气相色谱 - 质谱联用仪测定母血和脐血中的OCP水平。
结果
发现早产病例的母血和脐血中α-六氯环己烷、β-六氯环己烷、γ-六氯环己烷、总六氯环己烷、p,p'-滴滴伊和p,p'-滴滴涕的水平高于足月产病例。然而，仅观察到早产与β-六氯环己烷水平之间存在统计学上的显著关系。
结论
较高的β-六氯环己烷血水平可能与早产风险相关。
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