Biomedical Sciences Doctor Study, University of Veracruz, Xalapa, Mexico.
Bull Environ Contam Toxicol. 2011 Mar;86(3):289-93. doi: 10.1007/s00128-011-0204-4. Epub 2011 Feb 3.
The objective of the present study was to determine levels and calculate ratios of copartition coefficients among organochlorine pesticides β-HCH, pp'DDE, op'DDT and pp'DDT in maternal adipose tissue, maternal blood serum and umbilical blood serum of mother-infant pairs from Veracruz, Mexico. Organochlorine pesticides were analyzed in 70 binomials: maternal adipose tissue, maternal serum and umbilical cord serum samples, using gas chromatography with electron capture detection (GC-ECD). The results were expressed as mg/kg on fat basis. p,p'-DDE was the major organochlorine component, detected in every maternal adipose tissue (0.770 mg/kg), maternal serum sample (5.8 mg/kg on fat basis) and umbilical cord blood sample (6.9 mg/kg on fat basis). p,p'-DDT was detected at 0.101 mg/kg, 2.2 mg/kg and 5.9 mg/kg respectively, according to the order given above. β-HCH was detected at 0.027 mg/kg, 4.2 mg/kg and 28.0 mg/kg respectively. op'DDT was detected only in maternal adipose tissue at 0.011 mg/kg. The copartition coefficients among samples identify significant increases in concentrations from adipose tissue to maternal blood serum and to umbilical blood serum. The increase indicated that maternal adipose tissue released organochlorine pesticides to blood serum and that they are carried over to umbilical cord blood.
本研究的目的是测定来自墨西哥韦拉克鲁斯州母婴对中有机氯农药β-HCH、pp'DDE、op'DDT 和 pp'DDT 在母体脂肪组织、母体血清和脐血血清中的分配系数水平并计算其比值。采用气相色谱电子捕获检测法（GC-ECD）对 70 对母婴二联体的母体脂肪组织、母体血清和脐血血清样本中的有机氯农药进行了分析。结果以脂肪为基础的每千克毫克（mg/kg）表示。p,p'-DDE 是主要的有机氯成分，在每例母体脂肪组织（0.770 mg/kg）、母体血清样本（5.8 mg/kg 脂肪基础）和脐血血清样本（6.9 mg/kg 脂肪基础）中均有检出。p,p'-DDT 的检出量分别为 0.101 mg/kg、2.2 mg/kg 和 5.9 mg/kg。β-HCH 的检出量分别为 0.027 mg/kg、4.2 mg/kg 和 28.0 mg/kg。op'DDT 仅在母体脂肪组织中检出，为 0.011 mg/kg。样品间的分配系数表明，浓度从脂肪组织到母体血清再到脐血血清呈显著增加。这表明母体脂肪组织向血清释放有机氯农药，并且它们被转运到脐血中。
