Rogers Randall E, Higgins Stephen T, Silverman Kenneth, Thomas Colleen S, Badger Gary J, Bigelow George, Stitzer Maxine
Department of Psychiatry, University of Vermont, USA.
Psychol Addict Behav. 2008 Dec;22(4):544-50. doi: 10.1037/0893-164X.22.4.544.
Methadone-maintained cocaine abusers (N = 78) were randomly assigned to 1 of the following 52-week interventions: (a) usual care only (UC), (b) take-home methadone doses contingent on cocaine- and opiate-negative results (THM), or (c) take-home methadone doses for cocaine- and opiate-negative results and monetary-based vouchers contingent on cocaine-negative urinalysis results (THM + V). Cocaine use was assessed by urinalysis on a thrice-weekly schedule. Frequency and enjoyability of non-drug-related activities were assessed with the Pleasant Events Schedule (PES) at baseline, midtreatment, and end of treatment. The THM + V condition achieved the greatest abstinence from cocaine and opiate use, followed by the THM and UC conditions. The THM + V condition had the highest PES frequency ratings at midtreatment and at the end of treatment, followed by the THM and UC conditions. There were significant differences between the THM + V and UC conditions on 10 of 12 PES-derived subscales. Analyses revealed that abstinence mediated the effects of treatment condition on frequency ratings. There were no significant differences in enjoyability ratings. These results suggest that when contingency-management interventions increase abstinence from drug abuse, they also increase engagement in non-drug-related activities in naturalistic settings.
接受美沙酮维持治疗的可卡因滥用者(N = 78)被随机分配到以下52周干预措施中的一种:(a)仅接受常规护理(UC),(b)根据可卡因和阿片类药物检测呈阴性的结果给予带回家的美沙酮剂量(THM),或(c)根据可卡因和阿片类药物检测呈阴性的结果给予带回家的美沙酮剂量,并根据可卡因尿液分析呈阴性的结果给予货币代金券(THM + V)。通过每周三次的尿液分析评估可卡因的使用情况。在基线、治疗中期和治疗结束时,使用愉快事件量表(PES)评估与非药物相关活动的频率和愉悦度。THM + V组在可卡因和阿片类药物使用方面的戒断效果最佳,其次是THM组和UC组。THM + V组在治疗中期和治疗结束时的PES频率评分最高,其次是THM组和UC组。在12个源自PES的子量表中,THM + V组和UC组之间有10个存在显著差异。分析表明,戒断介导了治疗条件对频率评分的影响。愉悦度评分没有显著差异。这些结果表明,当应急管理干预措施增加药物滥用的戒断率时,它们也会增加在自然环境中参与非药物相关活动的程度。