State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
J Nat Prod. 2010 Jun 25;73(6):1112-6. doi: 10.1021/np100110u.
Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.
从凌云山鸡矢藤的地上部分分离得到 10 个新的贝壳杉烷二萜化合物， isolushinins A-J（1-10），以及 20 个已知化合物。通过光谱分析阐明了 1-10 的结构。对分离得到的几种化合物进行了对 HL-60、SMMC-7721、A-549、SK-BR-3 和 PANC-1 人癌细胞系的细胞毒性评价，其中一些表现出相当强的抑制活性。
