来自皱叶黄芩变种下的细胞毒贝壳杉烷二萜。

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2010 Jun 25;73(6):1112-6. doi: 10.1021/np100110u.

DOI:10.1021/np100110u

PMID:20521771

Abstract

Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.

摘要

从凌云山鸡矢藤的地上部分分离得到 10 个新的贝壳杉烷二萜化合物， isolushinins A-J（1-10），以及 20 个已知化合物。通过光谱分析阐明了 1-10 的结构。对分离得到的几种化合物进行了对 HL-60、SMMC-7721、A-549、SK-BR-3 和 PANC-1 人癌细胞系的细胞毒性评价，其中一些表现出相当强的抑制活性。