Matzuk Martin M
Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Dev Cell. 2009 Aug;17(2):160-1. doi: 10.1016/j.devcel.2009.07.020.
The transcription factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppressed by the microRNA let-7. In a recent issue of Nature, West and colleagues use a unique in vitro ES cell differentiation strategy to show that LIN28 is an essential regulator of PGC formation through inhibition of let-7 maturation and consequential induction of BLIMP1.
转录因子BLIMP1是原始生殖细胞（PGC）特化的主要调节因子，并受到微小RNA let-7的抑制。在最近一期的《自然》杂志上，韦斯特及其同事采用独特的体外胚胎干细胞分化策略，证明LIN28通过抑制let-7成熟并进而诱导BLIMP1，是PGC形成的关键调节因子。
