Sawetzki T, Rahmouni S, Bechinger C, Marr D W M
Physikalisches Institut, Universität Stuttgart, Pfaffenwaldring 57, 70550 Stuttgart, Germany.
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20141-5. doi: 10.1073/pnas.0808808105. Epub 2008 Dec 12.
Complex systems require their distinct components to function in a dynamic, integrated, and cooperative fashion. To accomplish this in current microfluidic networks, individual valves are often switched and pumps separately powered by using macroscopic methods such as applied external pressure. Direct manipulation and control at the single-device level, however, limits scalability, restricts portability, and hinders the development of massively parallel architectures that would take best advantage of microscale systems. In this article, we demonstrate that local geometry combined with a simple global field can not only reversibly drive component assembly but also power distinct devices in a parallel, locally uncoupled, and integrated fashion. By employing this single approach, we assemble and demonstrate the operation of check valves, mixers, and pistons within specially designed microfluidic environments. In addition, we show that by linking these individual components together, more complex devices such as pumps can be both fabricated and powered in situ.
复杂系统要求其不同组件以动态、集成和协作的方式运行。为了在当前的微流控网络中实现这一点,通常使用诸如施加外部压力等宏观方法来单独切换各个阀门并分别驱动泵。然而,在单设备级别进行直接操作和控制会限制可扩展性、便携性,并阻碍能够充分利用微尺度系统优势的大规模并行架构的发展。在本文中,我们证明局部几何形状与简单的全局场相结合,不仅可以可逆地驱动组件组装,还能以并行、局部解耦和集成的方式为不同的设备提供动力。通过采用这种单一方法,我们在专门设计的微流控环境中组装并展示了止回阀、混合器和活塞的运行。此外,我们表明,通过将这些单个组件连接在一起,可以原位制造和驱动更复杂的设备,如泵。