Flärdh Klas, Buttner Mark J
Department of Cell and Organism Biology, Lund University, Lund, Sweden.
Nat Rev Microbiol. 2009 Jan;7(1):36-49. doi: 10.1038/nrmicro1968.
During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves hormone-like extracellular signalling and coordination with an extraordinarily diverse secondary metabolism. Not only are the bacterial cytoskeleton and the machineries for cell-wall assembly, cell division and chromosome segregation reorganized during sporulation, but the developmental programme of these fascinating organisms also has many unusual elements, including the formation of a sporulating aerial mycelium and the production of a surfactant peptide and a hydrophobic sheath that allow cells to escape from the surface tension of the growth medium.
在丝状细菌链霉菌的生命周期中，形态分化与基本的生长和细胞周期过程紧密结合，同时也与真正复杂的多细胞行为相关，这种行为涉及类似激素的细胞外信号传导以及与极其多样的次级代谢的协调。在孢子形成过程中，不仅细菌细胞骨架以及细胞壁组装、细胞分裂和染色体分离的机制会发生重组，而且这些迷人生物体的发育程序还具有许多不寻常的元素，包括形成产孢气生菌丝体以及产生一种表面活性肽和一层疏水鞘，使细胞能够摆脱生长培养基的表面张力。
