Hepler Amanda B, Weir Bruce S
Department of Statistical Science, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Forensic Sci Int Genet. 2008 Jun;2(3):166-75. doi: 10.1016/j.fsigen.2007.12.003.
This study extends the current use of Bayesian networks by incorporating the effects of allelic dependencies in paternity calculations. The use of object-oriented networks greatly simplify the process of building and interpreting forensic identification models, allowing researchers to solve new, more complex problems. We explore two paternity examples: the most common scenario where DNA evidence is available from the alleged father, the mother and the child; a more complex casewhere DNA is not available from the alleged father, but is available from the alleged father's brother. Object-oriented networks are built, using HUGIN, for each example which incorporate the effects of allelic dependence caused by evolutionary relatedness.
本研究通过在亲子鉴定计算中纳入等位基因依赖性的影响,扩展了贝叶斯网络的当前应用。面向对象网络的使用极大地简化了构建和解释法医鉴定模型的过程,使研究人员能够解决新的、更复杂的问题。我们探讨了两个亲子鉴定案例:最常见的情况是有来自被指控父亲、母亲和孩子的DNA证据;一个更复杂的案例是没有被指控父亲的DNA,但有其兄弟的DNA。使用HUGIN为每个案例构建了面向对象网络,其中纳入了由进化相关性引起的等位基因依赖性的影响。