Ward Matthew S, Zhao Da You, Bernstein Paul S
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, Utah 84132 USA.
J Ocul Biol Dis Infor. 2008 Mar;1(1):12-8. doi: 10.1007/s12177-008-9008-0. Epub 2008 Jun 13.
The carotenoids lutein and zeaxanthin are believed to protect the human macula by absorbing blue light and quenching free radicals. Intestinal malabsorption syndromes such as celiac and Crohn's disease are known to cause deficiencies of lipid-soluble nutrients. We hypothesized that subjects with nutrient malabsorption syndromes will demonstrate lower carotenoid levels in the macula and blood, and that these lower levels may correlate with early-onset maculopathy. Resonance Raman spectrographic (RRS) measurements of macular carotenoid levels were collected from subjects with and without a history of malabsorption syndromes. Carotenoids were extracted from serum and analyzed by high performance liquid chromatography (HPLC). Subjects with malabsorption (n = 22) had 37% lower levels of macular carotenoids on average versus controls (n = 25, P < 0.001). Malabsorption was not associated with decreased serum carotenoid levels. Convincing signs of early maculopathy were not observed. We conclude that intestinal malabsorption results in lower macular carotenoid levels.
类胡萝卜素叶黄素和玉米黄质被认为可通过吸收蓝光和淬灭自由基来保护人类黄斑。已知诸如乳糜泻和克罗恩病等肠道吸收不良综合征会导致脂溶性营养素缺乏。我们推测，患有营养吸收不良综合征的受试者黄斑和血液中的类胡萝卜素水平会较低，且这些较低水平可能与早发性黄斑病变相关。我们从有和没有吸收不良综合征病史的受试者中收集了黄斑类胡萝卜素水平的共振拉曼光谱（RRS）测量数据。从血清中提取类胡萝卜素，并通过高效液相色谱（HPLC）进行分析。吸收不良的受试者（n = 22）黄斑类胡萝卜素水平平均比对照组（n = 25，P < 0.001）低37%。吸收不良与血清类胡萝卜素水平降低无关。未观察到早期黄斑病变的确切迹象。我们得出结论，肠道吸收不良会导致黄斑类胡萝卜素水平降低。
