Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs.

作者信息

Park Kyeng Min, Suh Kyungwon, Jung Hyuntae, Lee Don-Wook, Ahn Youngjoo, Kim Jeeyeon, Baek Kangkyun, Kim Kimoon

机构信息

Department of Chemistry, Pohang University of Science and Technology, Pohang, 790-784, Korea.

出版信息

Chem Commun (Camb). 2009 Jan 7(1):71-3. doi: 10.1039/b815009e. Epub 2008 Nov 13.

Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.