Catalytic asymmetric synthesis of the alkaloid (+)-myrtine.
作者信息
Pizzuti Maria Gabriella, Minnaard Adriaan J, Feringa Ben L
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, The Netherlands.
出版信息
Org Biomol Chem. 2008 Oct 7;6(19):3464-6. doi: 10.1039/b807575a. Epub 2008 Aug 19.
DOI:10.1039/b807575a
PMID:19082145
Abstract
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation-substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.
摘要
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