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先天性颌骨牙龈瘤:五例病例系列及文献复习

Congenital epulis of the jaw: a series of five cases and review of literature.

作者信息

Küpers A Marlijn, Andriessen Peter, van Kempen Muriel J P, van der Tol Ignaz G H, Baart Jacques A, Dumans Antoine G, van der Waal Isaäc

机构信息

Neonatal Intensive Care Unit, Máxima Medical Centre, PO Box 7777, 5500 MB, Veldhoven, The Netherlands.

出版信息

Pediatr Surg Int. 2009 Feb;25(2):207-10. doi: 10.1007/s00383-008-2304-8. Epub 2008 Dec 12.

DOI:10.1007/s00383-008-2304-8
PMID:19082830
Abstract

This article describes five cases of congenital epulis, a rare and benign swelling in the mouth of a newborn, which is not widely known. We present five cases: four cases presented as single pedunculated nodules of the gingiva and in one case two nodules were present. Of all, 50% were located at the maxilla. Excision was performed in four of the five cases and in one case, spontaneous regression was awaited. No recurrence was reported. The characteristic features of congenital epulis are a pedunculated, flesh-pink coloured tumour with a predominant occurrence on the anterior maxillary alveolar ridge in a female newborn. Although the aetiology is unknown, most authors suggest a mesenchymal, rather than an odontogenic, origin. Endogenous hormonal factors might influence growth prenatally. Histological findings include granular cells with eosinophilic cytoplasm and small, eccentric nuclei. Despite the fact that the lesion can be a striking sight, spontaneous regression is possible and can be awaited. Indications for non-radical excision under local anaesthesia are severe upper airway obstruction and interference with feeding technique. In conclusion, we provide clinical and histological information about congenital epulis, so that this entity will be more easily recognised and relevant information given to parents.

摘要

本文描述了5例先天性牙龈瘤,这是一种新生儿口腔中罕见的良性肿物,目前尚不广为人知。我们呈现5例病例:4例表现为牙龈单个带蒂结节,1例有2个结节。其中,50%位于上颌骨。5例中有4例行切除术,1例等待自然消退。未报告复发情况。先天性牙龈瘤的特征性表现为带蒂的肉粉色肿瘤,主要发生于女性新生儿的上颌前牙槽嵴。尽管病因不明,但大多数作者认为其起源于间充质,而非牙源性。内源性激素因素可能在产前影响其生长。组织学表现包括细胞质嗜酸性的颗粒细胞和小的偏心核。尽管该病变可能很引人注目,但自然消退是可能的,可以等待观察。局部麻醉下非根治性切除的指征为严重上呼吸道梗阻和影响喂养技术。总之,我们提供了关于先天性牙龈瘤的临床和组织学信息,以便更易于识别该疾病并向家长提供相关信息。

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Pathologica. 2021 Aug;113(4):280-284. doi: 10.32074/1591-951X-135.
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Congenital Epulis.先天性牙龈瘤

本文引用的文献

1
A newborn baby with a tumor protruding from the mouth. Diagnosis: congenital gingival granular cell tumor.一名新生儿口腔内有肿瘤突出。诊断:先天性牙龈颗粒细胞瘤。
Acta Dermatovenerol Alp Pannonica Adriat. 2007 Sep;16(3):128-30.
2
Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest.先天性颗粒细胞瘤(先天性龈瘤):一种具有多学科研究价值的病变。
Med Oral Patol Oral Cir Bucal. 2007 Oct 1;12(6):E428-30.
3
Complete spontaneous regression of congenital epulis in a baby by 8 months of age.一名婴儿的先天性牙龈瘤在8个月大时完全自发消退。
Eplasty. 2016 Feb 12;16:ic8. eCollection 2016.
4
Congenital epulis: a rare benign jaw tumor of newborn.先天性牙龈瘤:一种罕见的新生儿颌骨良性肿瘤。
J Neonatal Surg. 2012 Apr 1;1(2):31. eCollection 2012 Apr-Jun.
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Histogenesis and clinical analysis of 2 cases of congenital gingival granular cell tumour.2例先天性牙龈颗粒细胞瘤的组织发生及临床分析
J Clin Diagn Res. 2015 Jan;9(1):ZD03-5. doi: 10.7860/JCDR/2015/10048.5409. Epub 2015 Jan 1.
Int J Paediatr Dent. 2007 Jul;17(4):309-12. doi: 10.1111/j.1365-263X.2006.00795.x.
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Congenital epulis: a surprise in the neonate.先天性牙龈瘤:新生儿中的意外情况。
J Can Dent Assoc. 2006 Oct;72(8):747-50.
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Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor.先天性牙龈颗粒细胞瘤的产前诊断及多学科治疗方法
J Pediatr Surg. 2006 Oct;41(10):E35-8. doi: 10.1016/j.jpedsurg.2006.07.003.
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Congenital epulis.先天性龈瘤
J Craniofac Surg. 2005 Jan;16(1):161-4. doi: 10.1097/00001665-200501000-00033.
7
A rare case of multiple congenital epulis.一例罕见的多发性先天性牙龈瘤。
J Matern Fetal Neonatal Med. 2004 Nov;16 Suppl 2:55-8. doi: 10.1080/14767050410001727224.
8
Obstructive congenital gingival granular cell tumour.阻塞性先天性牙龈颗粒细胞瘤
Int J Pediatr Otorhinolaryngol. 2004 Dec;68(12):1567-71. doi: 10.1016/j.ijporl.2004.07.007.
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Anaesthetic management of the newborn with multiple congenital epulides.患有多发性先天性牙龈瘤新生儿的麻醉管理
Br J Anaesth. 2004 Nov;93(5):742-4. doi: 10.1093/bja/aeh255. Epub 2004 Sep 3.
10
Pathologic quiz case: a newborn with a midline buccal mucosa mass. Congenital gingival granular cell tumor (congenital epulis).病理问答病例:一名患有中线颊黏膜肿物的新生儿。先天性牙龈颗粒细胞瘤(先天性龈瘤)。
Arch Pathol Lab Med. 2004 May;128(5):585-6. doi: 10.5858/2004-128-585-PQCANW.