Montelius Kerstin, Karlsson Andreas O, Holmlund Gunilla
National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Artillerigatan 12, SE-58133 Linköping, Sweden.
Forensic Sci Int Genet. 2008 Jun;2(3):e49-52. doi: 10.1016/j.fsigen.2007.12.005. Epub 2008 Feb 14.
The modern Swedish population is a mixture of people that originate from different parts of the world. This is also the truth for the clients participating in the paternity cases investigated at the department. Calculations based on a Swedish frequency database only, could give us overestimated figures of probability and power of exclusion in cases including clients with a genetic background other than Swedish. Here, we describe allele frequencies regarding the markers in the Identifiler-kit. We have compared three sets of population samples; Swedish, European and non-European to investigate how these three groups of population samples differ. Also, all three population sets were compared to data reported from other European and non-European populations. Swedish allele frequencies for the 15 autosomal STRs included in the Identifiler kit were obtained from unrelated blood donors with Swedish names. The European and non-European frequencies were based on DNA-profiles of alleged fathers from our paternity cases in 2005 and 2006.
现代瑞典人口是来自世界不同地区人群的混合体。对于在该部门接受调查的亲子鉴定案件中的客户来说,情况也是如此。仅基于瑞典频率数据库进行计算,在涉及具有非瑞典遗传背景客户的案件中,可能会使我们得到高估的概率和排除能力数据。在此,我们描述了Identifiler试剂盒中各标记的等位基因频率。我们比较了三组人群样本:瑞典人、欧洲人和非欧洲人,以研究这三组人群样本之间的差异。此外,还将所有这三组人群样本与其他欧洲和非欧洲人群报告的数据进行了比较。Identifiler试剂盒中包含的15个常染色体STR的瑞典等位基因频率是从具有瑞典名字的无关献血者那里获得的。欧洲人和非欧洲人的频率是基于2005年和2006年我们亲子鉴定案件中被指控父亲的DNA图谱得出的。