Cannon Christopher P
Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Am J Cardiol. 2008 Dec 22;102(12A):5L-9L. doi: 10.1016/j.amjcard.2008.09.067.
Metabolic syndrome and type 2 diabetes mellitus are individually associated with increased cardiovascular risk; furthermore, the combination of metabolic syndrome with diabetes accentuates this risk. An atherogenic dyslipidemia characterized by elevated triglycerides, low high-density lipoprotein cholesterol, or both conditions is a key modifiable risk factor associated with both conditions. As the development of this atherogenic mixed dyslipidemia precedes the onset of overt glycemia and the clinical diagnosis of diabetes, early effective intervention is recommended to reduce the risk of premature cardiovascular disease morbidity and mortality.
代谢综合征和2型糖尿病分别与心血管风险增加相关；此外，代谢综合征与糖尿病并存会加剧这种风险。以甘油三酯升高、高密度脂蛋白胆固醇降低或两者兼有为特征的致动脉粥样硬化血脂异常是与这两种情况相关的关键可改变风险因素。由于这种致动脉粥样硬化混合性血脂异常在明显高血糖和糖尿病临床诊断之前就已出现，因此建议进行早期有效干预，以降低心血管疾病过早发病和死亡的风险。
