Jeffery Alison N, Murphy Michael J, Metcalf Brad S, Hosking Joanne, Voss Linda D, English Patrick, Sattar Naveed, Wilkin Terence J
Department of Endocrinology & Metabolism, Peninsula Medical School, Plymouth Campus, UK.
Int J Pediatr Obes. 2008;3(3):130-40. doi: 10.1080/17477160801954538.
Adiponectin, a hormone produced and secreted by adipocytes, is present in circulation in high circulating concentrations, suggesting an important physiological role. An indirect regulator of glucose metabolism, adiponectin increases insulin sensitivity, improves glucose tolerance and inhibits inflammation. Plasma adiponectin relates inversely to adiposity and, importantly, reflects the sequelae of accumulation of excess adiposity. The role of adiponectin in adults has been explored in detail. Studies in children are now available and, given the increasing rates of childhood obesity, it is important to establish the role of adiponectin in mediating insulin resistance and cardiovascular disease in this age group. This paper reviews the regulation of adiponectin, its effect on body mass, glucose metabolism and cardiovascular risk in infants, children and adolescents. It demonstrates clear links between adiponectin and features of the metabolic syndrome in obese children and adolescents. However, adiponectin's role as a predictor of metabolic dysfunction in healthy, normal-weight youngsters is less clear.
脂联素是一种由脂肪细胞产生和分泌的激素，以高循环浓度存在于血液循环中，提示其具有重要的生理作用。作为葡萄糖代谢的间接调节因子，脂联素可增加胰岛素敏感性、改善糖耐量并抑制炎症。血浆脂联素与肥胖呈负相关，重要的是，它反映了过量脂肪堆积的后果。脂联素在成年人中的作用已得到详细研究。目前已有针对儿童的研究，鉴于儿童肥胖率不断上升，明确脂联素在该年龄组中介导胰岛素抵抗和心血管疾病的作用非常重要。本文综述了脂联素的调节机制及其对婴儿、儿童和青少年体重、葡萄糖代谢及心血管风险的影响。研究表明，肥胖儿童和青少年的脂联素与代谢综合征特征之间存在明显联系。然而，脂联素在健康、体重正常的青少年中作为代谢功能障碍预测指标的作用尚不清楚。
