上游结合因子被隔离到单纯疱疹病毒1型复制区室中。
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments.
作者信息
Stow Nigel D, Evans Vanessa C, Matthews David A
机构信息
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
出版信息
J Gen Virol. 2009 Jan;90(Pt 1):69-73. doi: 10.1099/vir.0.006353-0.
Abstract
Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.
摘要
先前的报告显示，腺病毒将核仁蛋白上游结合因子（UBF）招募到腺病毒DNA复制中心。在此，我们报告，尽管单纯疱疹病毒1型（HSV-1）具有不同的病毒DNA复制模式，但它也将UBF招募到病毒DNA复制中心。此外，与腺病毒一样，增强型绿色荧光蛋白标记的UBF融合蛋白会抑制病毒DNA复制。我们提出，UBF被招募到复制区室以辅助HSV-1 DNA的复制。此外，这是核仁成分在病毒生命周期中作用的又一个例子。
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