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1
L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.在乙醇存在的情况下，通过丙酮酸脱氢酶复合体缺陷型谷氨酸棒杆菌生长过程中产生L-缬氨酸，或通过转录调节因子SugR的失活产生L-缬氨酸。
Appl Environ Microbiol. 2009 Feb;75(4):1197-200. doi: 10.1128/AEM.02351-08. Epub 2008 Dec 16.
2
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J Ind Microbiol Biotechnol. 2010 Mar;37(3):263-70. doi: 10.1007/s10295-009-0669-x. Epub 2009 Dec 11.
3
Corynebacterium glutamicum tailored for high-yield L-valine production.经改造用于高产L-缬氨酸生产的谷氨酸棒杆菌。
Appl Microbiol Biotechnol. 2008 Jun;79(3):471-9. doi: 10.1007/s00253-008-1444-z. Epub 2008 Apr 1.
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Appl Environ Microbiol. 2013 Sep;79(18):5566-75. doi: 10.1128/AEM.01741-13. Epub 2013 Jul 8.
5
L-valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum.利用丙酮酸脱氢酶复合体缺陷型谷氨酸棒杆菌生产L-缬氨酸。
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6
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7
The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum.DeoR 型转录调节因子 SugR 作为谷氨酸棒杆菌中编码磷酸烯醇丙酮酸：糖磷酸转移酶系统（PTS）的基因的阻遏物。
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Impact of CO/HCO Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains.CO/HCO 可用性对丙酮酸脱氢酶复合物缺陷型谷氨酸棒状杆菌补料流加的影响。
J Bacteriol. 2019 Sep 20;201(20). doi: 10.1128/JB.00387-19. Print 2019 Oct 15.
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Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.一种基因编码生物传感器在丙酮酸脱氢酶复合物缺陷型谷氨酸棒杆菌菌株中用于L-缬氨酸生产的活细胞成像的应用。
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Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity.利用麦芽糖增加谷氨酸棒杆菌的葡萄糖利用率及其在 L-缬氨酸生产中的应用。
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Metabolic engineering of Corynebacterium glutamicum for producing branched chain amino acids.谷氨酸棒杆菌的代谢工程生产支链氨基酸。
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L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects.基于系统代谢工程的谷氨酸棒杆菌 L-缬氨酸生产：进展与展望。
Amino Acids. 2021 Sep;53(9):1301-1312. doi: 10.1007/s00726-021-03066-9. Epub 2021 Aug 16.
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Impact of CO/HCO Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains.CO/HCO 可用性对丙酮酸脱氢酶复合物缺陷型谷氨酸棒状杆菌补料流加的影响。
J Bacteriol. 2019 Sep 20;201(20). doi: 10.1128/JB.00387-19. Print 2019 Oct 15.
6
Metabolic engineering of glucose uptake systems in Corynebacterium glutamicum for improving the efficiency of L-lysine production.在谷氨酸棒杆菌中葡萄糖摄取系统的代谢工程改造，以提高 L-赖氨酸生产效率。
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Engineering Corynebacterium glutamicum for the production of 2,3-butanediol.工程改造谷氨酸棒杆菌用于生产2,3-丁二醇。
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本文引用的文献

1
Corynebacterium glutamicum tailored for high-yield L-valine production.经改造用于高产L-缬氨酸生产的谷氨酸棒杆菌。
Appl Microbiol Biotechnol. 2008 Jun;79(3):471-9. doi: 10.1007/s00253-008-1444-z. Epub 2008 Apr 1.
2
Regulation of expression of general components of the phosphoenolpyruvate: carbohydrate phosphotransferase system (PTS) by the global regulator SugR in Corynebacterium glutamicum.谷氨酸棒杆菌中全局调控因子SugR对磷酸烯醇丙酮酸：糖磷酸转移酶系统（PTS）一般组分表达的调控
Appl Microbiol Biotechnol. 2008 Feb;78(2):309-18. doi: 10.1007/s00253-007-1313-1. Epub 2008 Jan 9.
3
The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum.DeoR 型转录调节因子 SugR 作为谷氨酸棒杆菌中编码磷酸烯醇丙酮酸：糖磷酸转移酶系统（PTS）的基因的阻遏物。
BMC Mol Biol. 2007 Nov 15;8:104. doi: 10.1186/1471-2199-8-104.
4
Ethanol catabolism in Corynebacterium glutamicum.谷氨酸棒杆菌中的乙醇分解代谢
J Mol Microbiol Biotechnol. 2008;15(4):222-33. doi: 10.1159/000107370. Epub 2007 Aug 13.
5
The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression.谷氨酸棒杆菌中的乙醇脱氢酶基因adhA受到碳分解代谢物阻遏作用的调控。
J Bacteriol. 2007 Oct;189(20):7408-16. doi: 10.1128/JB.00791-07. Epub 2007 Aug 10.
6
Transcriptionally regulated adhA gene encodes alcohol dehydrogenase required for ethanol and n-propanol utilization in Corynebacterium glutamicum R.转录调控的adhA基因编码谷氨酸棒杆菌R利用乙醇和正丙醇所需的乙醇脱氢酶。
Appl Microbiol Biotechnol. 2007 Oct;76(6):1347-56. doi: 10.1007/s00253-007-1094-6. Epub 2007 Jul 24.
7
Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation.基于转录组分析和计算机基因敲除模拟的大肠杆菌代谢工程用于L-缬氨酸的生产
Proc Natl Acad Sci U S A. 2007 May 8;104(19):7797-802. doi: 10.1073/pnas.0702609104. Epub 2007 Apr 26.
8
Systems biology for industrial strains and fermentation processes--example: amino acids.工业菌株与发酵过程的系统生物学——实例：氨基酸
J Biotechnol. 2007 Apr 30;129(2):181-90. doi: 10.1016/j.jbiotec.2007.01.031. Epub 2007 Feb 11.
9
Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum.丙酮酸脱氢酶复合体缺乏对谷氨酸棒杆菌生产L-赖氨酸的影响。
Appl Microbiol Biotechnol. 2007 Sep;76(3):615-23. doi: 10.1007/s00253-007-0904-1. Epub 2007 Mar 2.
10
L-valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum.利用丙酮酸脱氢酶复合体缺陷型谷氨酸棒杆菌生产L-缬氨酸。
Appl Environ Microbiol. 2007 Apr;73(7):2079-84. doi: 10.1128/AEM.02826-06. Epub 2007 Feb 9.

在乙醇存在的情况下，通过丙酮酸脱氢酶复合体缺陷型谷氨酸棒杆菌生长过程中产生L-缬氨酸，或通过转录调节因子SugR的失活产生L-缬氨酸。

L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.

作者信息

Blombach Bastian, Arndt Annette, Auchter Marc, Eikmanns Bernhard J

机构信息

Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.

出版信息

Appl Environ Microbiol. 2009 Feb;75(4):1197-200. doi: 10.1128/AEM.02351-08. Epub 2008 Dec 16.

DOI:10.1128/AEM.02351-08
PMID:19088318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2643581/
Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

摘要

谷氨酸棒杆菌丙酮酸脱氢酶复合体缺陷型菌株仅在生长所需的乙酸盐耗尽后才能从葡萄糖产生L-缬氨酸。在此我们表明，在生长阶段使DeoR型转录调节因子SugR失活或用乙醇替代乙酸盐，会导致高效的L-缬氨酸生产。