Aota N, Hirahara K, Kano Y, Fukuoka T, Yamada A, Shiohara T
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
Dermatology. 2009;218(3):275-7. doi: 10.1159/000187619. Epub 2008 Dec 16.
Drug-induced hypersensitivity syndrome (DIHS) is a severe form of drug eruptions associated with viral reactivations. Autoimmune diseases have been reported to develop several months or years after the resolution of DIHS. We describe a 36-year-old man with cervical lymphadenopathy and an erythematous eruption affecting the face and neck, which evolved into clinically evident systemic lupus erythematosus. He had had an episode of DIHS 4 years previously, in which human herpesvirus-6 and Epstein-Barr virus (EBV) were reactivated. Expression of EBV-encoded RNA was detected in the lymph node. On the basis of findings in this patient, we suggest that EBV is pathogenically important in the sequence of events leading to the onset of systemic lupus erythematosus and that patients with a history of DIHS may be at a risk of eventually developing autoimmune diseases.
药物性超敏反应综合征（DIHS）是一种与病毒再激活相关的严重药物疹形式。据报道，自身免疫性疾病在DIHS消退数月或数年之后出现。我们描述了一名36岁男性，有颈部淋巴结病以及累及面部和颈部的红斑疹，后来发展为临床明显的系统性红斑狼疮。他4年前曾有过一次DIHS发作，当时人类疱疹病毒6型和爱泼斯坦-巴尔病毒（EBV）被再激活。在淋巴结中检测到EBV编码RNA的表达。基于该患者的发现，我们认为EBV在导致系统性红斑狼疮发病的一系列事件中具有致病重要性，并且有DIHS病史的患者可能最终有患自身免疫性疾病的风险。
