光动力治疗后息肉样脉络膜血管病变的复发
Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy.
作者信息
Yamashiro Kenji, Tsujikawa Akitaka, Nishida Akihiro, Mandai Michiko, Kurimoto Yasuo
机构信息
Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Department of Regenerative Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan.
出版信息
Jpn J Ophthalmol. 2008 Nov-Dec;52(6):457-462. doi: 10.1007/s10384-008-0582-2. Epub 2008 Dec 17.
PURPOSE
To evaluate the recurrence of polypoidal lesions after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV).
METHODS
This is a retrospective review of data on 28 patients with PCV treated with PDT. The recurrent polypoidal lesions were observed with fluorescein and indocyanine green angiography.
RESULTS
In 26 of the 28 eyes the PCV remained inactive for more than 12 months after one to three treatments with PDT. Recurrence of the polypoidal lesions after more than a 12-month inactive period was reported in eight eyes: three at 15 months, two at 18 months, and three at 21 months. Kaplan-Meier estimates of recurrence were 11.5% at 15 months, 20.4% at 18 months, and 38.8% at 21 months, with no subsequent recurrence until passage of 36 months of inactivity after the last PDT. Additional PDT after recurrence improved or preserved visual acuity in 80% of those treated compared to the visual acuity before the first PDT.
CONCLUSIONS
Recurrence of PCV occurs in about 40% of eyes treated for PCV even after a long period of inactivity, so careful follow-up is needed.
目的
评估光动力疗法（PDT）治疗息肉样脉络膜血管病变（PCV）后息肉样病变的复发情况。
方法
这是一项对28例接受PDT治疗的PCV患者的数据进行的回顾性研究。通过荧光素和吲哚菁绿血管造影观察复发性息肉样病变。
结果
在28只眼中，有26只眼在接受一至三次PDT治疗后PCV保持静止状态超过12个月。报告了8只眼在静止期超过12个月后息肉样病变复发：3只在15个月时复发，2只在18个月时复发，3只在21个月时复发。Kaplan-Meier法估计的复发率在15个月时为11.5%，18个月时为20.4%，21个月时为38.8%，在最后一次PDT后静止36个月之前无后续复发情况。与首次PDT前的视力相比，复发后接受额外PDT治疗的患者中80%的视力得到改善或保持。
结论
即使经过长时间的静止期，接受PCV治疗的眼中约40%会出现PCV复发，因此需要仔细随访。
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