Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Jpn J Ophthalmol. 2011 May;55(3):241-247. doi: 10.1007/s10384-011-0006-6. Epub 2011 May 11.
To investigate the characteristics of eyes with polypoidal choroidal vasculopathy (PCV) which develop secondary classic choroidal neovascularization (CNV) after photodynamic therapy (PDT).
We retrospectively reviewed the records of 64 eyes of 64 PCV patients (43 men, 21 women; mean age ± standard deviation, 72.7 ± 8.6 years), who were followed-up for at least 1 year after the initial PDT. There was no evidence of classic CNV in any of the subject eyes on fluorescein angiography (FA) at the first PDT. Eyes which developed of secondary classic CNV after PDT were classified as the CNV group and the other eyes as the No-CNV group.
Secondary classic CNV developed after PDT in 10 (15.6%) of the 64 eyes. Six patients developed CNV within 1 year after the first PDT. Multivariate logistic regression analysis for the baseline factors related to CNV development, including age, gender, greatest linear dimension, and the lesion components, revealed that in the CNV group the age was significantly younger (p = 0.037) and the incidence of retinal edema was significantly greater (p = 0.041) than in the No-CNV group.
Secondary classic CNV tends to develop after PDT in PCV eyes in younger patients with retinal edema.
研究光动力疗法（PDT）后发生继发性典型脉络膜新生血管（CNV）的息肉样脉络膜血管病变（PCV）眼的特征。
我们回顾性分析了 64 只 PCV 眼（43 名男性，21 名女性；平均年龄±标准差，72.7±8.6 岁）的记录，这些患者在初始 PDT 后至少随访 1 年。在最初的 PDT 时，所有受检眼的荧光素血管造影（FA）均无典型 CNV 的证据。在 PDT 后发生继发性典型 CNV 的眼被分为 CNV 组，其他眼为 No-CNV 组。
64 只眼中有 10 只（15.6%）在 PDT 后出现继发性典型 CNV。6 例患者在首次 PDT 后 1 年内出现 CNV。对与 CNV 发展相关的基线因素（包括年龄、性别、最大线性维度和病变成分）进行多变量逻辑回归分析，结果表明 CNV 组的年龄显著较小（p=0.037），视网膜水肿的发生率显著较高（p=0.041）。
在 PDT 后，PCV 眼的继发性典型 CNV 更容易发生在有视网膜水肿的年轻患者中。
