Jin Qu, Schexnailder Patrick, Gaharwar Akhilesh K, Schmidt Gudrun
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA.
Macromol Biosci. 2009 Oct 8;9(10):1028-35. doi: 10.1002/mabi.200900080.
The compositions and the multi phase structures of bio-nanocomposite hydrogels made from silicate cross-linked PEO and chitosan are related to some of their physical and biological properties. The gels are injectable and self-healing because the cross-linking is physical and reversible under deformation. The presence of chitosan aggregates affects the viscoelastic properties and reinforces the hydrogel network. The chitosan adds advantageous properties to the hydrogel such as enhanced cell spreading and adhesion. In vitro biocompatibility data indicate that NIH 3T3 fibroblasts grow and proliferate on the bio-nanocomposite hydrogel as well as on hydrogel films.
由硅酸盐交联的聚环氧乙烷（PEO）和壳聚糖制成的生物纳米复合水凝胶的组成和多相结构与其一些物理和生物学特性有关。这些凝胶是可注射且自愈的，因为交联是物理性的且在变形下是可逆的。壳聚糖聚集体的存在会影响粘弹性特性并增强水凝胶网络。壳聚糖为水凝胶增添了诸如增强细胞铺展和黏附等有利特性。体外生物相容性数据表明，NIH 3T3成纤维细胞在生物纳米复合水凝胶以及水凝胶薄膜上生长和增殖。
